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Canada's Assisted Human Reproduction Act: Pragmatic Reforms in Support of Research

Published on Jul 10, 2019in Frontiers of Medicine in China
· DOI :10.3389/fmed.2019.00157
Tania Bubela2
Estimated H-index: 2
(SFU: Simon Fraser University),
Erika Kleiderman5
Estimated H-index: 5
(McGill University)
+ 4 AuthorsBartha Maria Knoppers49
Estimated H-index: 49
(McGill University)
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Abstract
Canada’s Assisted Human Reproduction Act is long overdue for Parliamentary review. We argue that the current regulation of research using human reproductive materials is not proportionate, not responsive to the uncertain threats posed to human and environmental health and safety, and is not considerate of diverse values in a democratic society. We propose tailored regulatory carve-outs for in vitro research for currently prohibited activities, such as gene editing, and for the exercise of Ministerial Discretion for access by Canadians to experimental in vivo interventions that are currently prohibited, such as mitochondrial replacement therapy. Our recommendations are bounded by constitutional constraints that recognize political and practical challenges in keeping oversight of this research under Federal jurisdiction, whether conducted in academic or private sectors. The proposed nuanced regulatory scheme should be overseen by a new national Agency, modeled on a blend of the Canadian Stem Cell Oversight Committee and Assisted Human Reproduction Canada.
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References48
Newest
Published on May 20, 2019in Nature Biotechnology31.86
I. Glenn Cohen14
Estimated H-index: 14
(Harvard University),
Eli Y. Adashi61
Estimated H-index: 61
(Brown University),
Vardit Ravitsky14
Estimated H-index: 14
(UdeM: Université de Montréal)
Published on Apr 1, 2019in Cell Stem Cell21.46
Tsutomu Sawai2
Estimated H-index: 2
(Kyoto University),
Taichi Hatta2
Estimated H-index: 2
(Kyoto University),
Misao Fujita8
Estimated H-index: 8
(Kyoto University)
Published on Apr 1, 2019in Nature43.07
Harald König19
Estimated H-index: 19
Published on Mar 8, 2019in Science41.04
Dennis Normile24
Estimated H-index: 24
Responding to the outcry over the news that one of its scientists produced genetically altered babies, the Chinese government last week issued draft regulations that would require national approval for clinical research involving gene editing and other "high-risk biomedical technologies." The need for new regulations was highlighted in November 2018 when He Jiankui, then of Southern University of Science and Technology in Shenzhen, China, announced that he had used the CRISPR genome-editing syst...
Published on Mar 7, 2019in The New England Journal of Medicine70.67
R. Alta Charo13
Estimated H-index: 13
(UW: University of Wisconsin-Madison)
Rogues and Regulation of Germline Editing Calling for a moratorium on germline editing won’t stop rogue actors. Instead, an “ecosystem” approach to regulation might minimize premature, unwarranted,...
Published on Mar 1, 2019in Trends in Molecular Medicine11.03
Eli Y. Adashi61
Estimated H-index: 61
(Brown University),
I. Glenn Cohen14
Estimated H-index: 14
(Harvard University)
+ 2 AuthorsKatsuhiko Hayashi (Kyushu University)
The implications of scientific breakthroughs are rarely faced up to in advance of their realization. Stem cell-derived human gametes, a disruptive technology in waiting, are likely to recapitulate this historic pattern absent active intervention. Herein we call for the conduct of thoughtful ante hoc deliberations on the prospect of stem cell-derived human gametes with an eye toward minimizing potential untoward post ho c regulatory or statutory impositions.
Published on Mar 1, 2019in Nature43.07
Sara Reardon19
Estimated H-index: 19
Advisory committee calls for a global registry of studies that involve editing the human genome. Advisory committee calls for a global registry of studies that involve editing the human genome.
Published on Mar 1, 2019in Nature43.07
Eric S. Lander245
Estimated H-index: 245
,
Françoise Baylis23
Estimated H-index: 23
+ 15 AuthorsDavid R. Liu70
Estimated H-index: 70
Eric Lander, Francoise Baylis, Feng Zhang, Emmanuelle Charpentier, Paul Berg and specialists from seven countries call for an international governance framework. Eric Lander, Francoise Baylis, Feng Zhang, Emmanuelle Charpentier, Paul Berg and specialists from seven countries call for an international governance framework.
Published on Jan 28, 2019in Canadian Medical Association Journal6.94
Bartha Maria Knoppers49
Estimated H-index: 49
(McGill University),
Erika Kleiderman5
Estimated H-index: 5
(McGill University)
KEY POINTS The response to the announcement in China on Nov. 25, 2018, of the “first clustered regularly interspaced short palindromic repeats [CRISPR] babies”[1][1] is reminiscent of that surrounding the 1978 birth by in vitro fertilization of Louise Brown, the “first test-tube baby.” Will
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Published on 2019in Journal of Community Genetics
Erika Kleiderman5
Estimated H-index: 5
(McGill University),
Ian Stedman (York University)
Human germline genome editing may prove to be especially poignant for members of the rare disease community, many of whom are diagnosed with monogenic diseases. This community lacks broad representation in the literature surrounding genome editing, notably in Canada, yet is likely to be directly affected by eventual clinical applications of this technology. Although not generalizable, the literature does offer some commonalities regarding the experiences of rare disease patients. This manuscript...