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Published on Jan 22, 2019in BMC Genomics 3.50
Carlos F. Prada (Universidad del Tolima), Jeffrey L. Boore42
Estimated H-index: 42
Although animal mitochondrial DNA sequences are known to evolve rapidly, their gene arrangements often remain unchanged over long periods of evolutionary time. Therefore, comparisons of mitochondrial genomes may result in significant insights into the evolution both of organisms and of genomes. Mammalian mitochondrial genomes recently published in the GenBank database of NCBI show numerous rearrangements in various regions of the genome, from which it may be inferred that the mammalian mitochond...
Published on Apr 29, 2019in EMBO Reports 8.38
Shan Jiang (KI: Karolinska Institutet), Camilla Koolmeister (KI: Karolinska Institutet)+ 15 AuthorsMin Jiang2
Estimated H-index: 2
(MPG: Max Planck Society)
Abstract Regulation of replication and expression of mitochondrial DNA (mtDNA) is essential for cellular energy conversion via oxidative phosphorylation. The mitochondrial transcription elongation factor (TEFM) has been proposed to regulate the switch between transcription termination for replication primer formation and processive, near genome‐length transcription for mtDNA gene expression. Here, we report that Tefm is essential for mouse embryogenesis and that levels of promoter‐distal mitocho...
Published on Jan 3, 2019in PLOS Genetics 5.22
Viktor Posse7
Estimated H-index: 7
(University of Gothenburg),
Ali Al-Behadili1
Estimated H-index: 1
(University of Gothenburg)
+ 5 AuthorsClaes M. Gustafsson38
Estimated H-index: 38
(University of Gothenburg)
This work was supported by Swedish Research Council (www.vr.se) to ARC (2014-6466), MF (2013-3621), and CMG (2017-01257); the Swedish Foundation for Strategic Research (ICA14-0060 to ARC), Swedish Cancer Foundation (www.cancerfonden.se) to MF (CAN 2016/816) and CMG (CAN 2017/631); European Research Council consolidator grant (erc.europa.eu) to MF (DELMIT); the IngaBritt and Arne Lundberg Foundation (www.lundbergsstiftelsen.se) to MF; the Knut and Alice Wallenberg Foundation (kaw.wallenberg.org) ...
Published on Nov 1, 2017in Cell 36.22
Hauke S. Hillen2
Estimated H-index: 2
(MPG: Max Planck Society),
Yaroslav I. Morozov8
Estimated H-index: 8
(Rowan University)
+ 2 AuthorsPatrick Cramer62
Estimated H-index: 62
(MPG: Max Planck Society)
Summary Transcription in human mitochondria is driven by a single-subunit, factor-dependent RNA polymerase (mtRNAP). Despite its critical role in both expression and replication of the mitochondrial genome, transcription initiation by mtRNAP remains poorly understood. Here, we report crystal structures of human mitochondrial transcription initiation complexes assembled on both light and heavy strand promoters. The structures reveal how transcription factors TFAM and TFB2M assist mtRNAP to achiev...
Published on Nov 1, 2017in Cell 36.22
Hauke S. Hillen2
Estimated H-index: 2
(MPG: Max Planck Society),
Andrey V. Parshin4
Estimated H-index: 4
(Rowan University)
+ 8 AuthorsPatrick Cramer62
Estimated H-index: 62
(MPG: Max Planck Society)
Summary In human mitochondria, transcription termination events at a G-quadruplex region near the replication origin are thought to drive replication of mtDNA by generation of an RNA primer. This process is suppressed by a key regulator of mtDNA—the transcription factor TEFM. We determined the structure of an anti-termination complex in which TEFM is bound to transcribing mtRNAP. The structure reveals interactions of the dimeric pseudonuclease core of TEFM with mobile structural elements in mtRN...
Published on Jul 26, 2017in eLife 7.55
Akira Uchida3
Estimated H-index: 3
(PSU: Pennsylvania State University),
Divakaran Murugesapillai4
Estimated H-index: 4
(NU: Northeastern University)
+ 8 AuthorsMark C. Williams34
Estimated H-index: 34
(NU: Northeastern University)
Human mtDNA contains three promoters, suggesting a need for differential expression of the mitochondrial genome. Studies of mitochondrial transcription have used a reductionist approach, perhaps masking differential regulation. Here we evaluate transcription from light-strand (LSP) and heavy-strand (HSP1) promoters using templates that mimic their natural context. These studies reveal sequences upstream, hypervariable in the human population (HVR3), and downstream of the HSP1 transcription start...
Published on Jan 25, 2017in Nucleic Acids Research 11.15
Urmimala Basu1
Estimated H-index: 1
(RU: Rutgers University),
Shemaila Sultana3
Estimated H-index: 3
(RU: Rutgers University)
+ 1 AuthorsSmita S. Patel49
Estimated H-index: 49
(RU: Rutgers University)
Published on Oct 1, 2016in Cell 36.22
Aindrila Chatterjee1
Estimated H-index: 1
(MPG: Max Planck Society),
Janine Seyfferth2
Estimated H-index: 2
(MPG: Max Planck Society)
+ 14 AuthorsOliver Kretz28
Estimated H-index: 28
(University of Freiburg)
A functional crosstalk between epigenetic regulators and metabolic control could provide a mechanism to adapt cellular responses to environmental cues. We report that the well-known nuclear MYST family acetyl transferase MOF and a subset of its non-specific lethal complex partners reside in mitochondria. MOF regulates oxidative phosphorylation by controlling expression of respiratory genes from both nuclear and mtDNA in aerobically respiring cells. MOF binds mtDNA, and this binding is dependent ...
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