All That Glitters is Not Gold in Vedolizumab Therapy for Patients With Inflammatory Bowel Diseases and Primary Sclerosing Cholangitis

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease highly associated with inflammatory bowel disease (IBD). PSC is characterized by inflammation of the intrahepatic and extrahepatic bile ducts, leading to destruction of the biliary epithelium, periductular fibrosis, and eventually end-stage liver disease. PSC is also associated to a significant risk of cholangiocarcinoma and gall bladder carcinoma.1Eksteen B. The...