Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization

Volume: 50, Issue: 6, Pages: 755 - 766.e6
Published: Sep 1, 2019
Abstract
•Nutrients regulate the phospholipid:diacylglycerol acyltransferase Lro1•Lro1 targets the INM subdomain bordering the nucleolus•Lro1 is active at the INM and can sustain cell survival during starvation•Compartmentalized synthesis of nuclear TG is important for nuclear envelope integrity Cells dynamically adjust organelle organization in response to growth and environmental cues. This requires regulation of synthesis of phospholipids, the...
Paper Details
Title
Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization
Published Date
Sep 1, 2019
Volume
50
Issue
6
Pages
755 - 766.e6
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