Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome
Abstract
Propofol infusion syndrome (PRIS) is an uncommon life-threatening complication observed most often in patients receiving high-dose propofol. High-dose propofol treatment with a prolonged duration can damage the immune system. However, the associated molecular mechanisms remain unclear. An increasing number of clinical and experimental observations have demonstrated that tissue-resident macrophages play a critical role in immune regulation during...
Paper Details
Title
Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome
Published Date
Jul 17, 2019
Journal
Volume
10
Issue
8
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Notes
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