The functional complexity of the RNA-binding protein Yra1: mRNA biogenesis, genome stability and DSB repair
Abstract
The mRNA export adaptor Yra1 is essential in S. cerevisiae, and conserved from yeast to human (ALY/REF). It is well characterized for its function during transcription elongation, 3' processing and mRNA export. Recently, different studies linked Yra1 to genome stability showing that Yra1 overexpression causes DNA Double Strand Breaks through DNA:RNA hybrids stabilization, and that Yra1 depletion affects DSB repair. However, the mechanisms...
Paper Details
Title
The functional complexity of the RNA-binding protein Yra1: mRNA biogenesis, genome stability and DSB repair
Published Date
Jul 10, 2019
Journal
Volume
66
Issue
1
Pages
63 - 71
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