Design and evaluation of a solid dispersion and thermosensitive hydrogel combined local delivery system of dimethoxycurcumin

Dimethoxycurcumin (DiMC) is an analogue of curcumin highlighted with its superior pro-oxidant potent, immunomodulatory property and anti-tumor activity. However, bioavailability of DiMC is low due to its poor water solubility. To address this issue, a solid dispersion (SD) and injectable thermosensitive hydrogel combined DiMC delivery system was developed. First, carriers including polyvinylpyrrolidone K30 (PVP–K30), polyethylene glycol 4000...