Stable enhancers are active in development, and fragile enhancers are associated with evolutionary adaptation
Abstract
Despite continual progress in the identification and characterization of trait- and disease-associated variants that disrupt transcription factor (TF)-DNA binding, little is known about the distribution of TF binding deactivating mutations (deMs) in enhancer sequences. Here, we focus on elucidating the mechanism underlying the different densities of deMs in human enhancers. We identify two classes of enhancers based on the density of nucleotides...
Paper Details
Title
Stable enhancers are active in development, and fragile enhancers are associated with evolutionary adaptation
Published Date
Jul 15, 2019
Journal
Volume
20
Issue
1
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