Family Clustering of Autoimmune Vitiligo Results Principally from Polygenic Inheritance of Common Risk Alleles
Abstract
Vitiligo is an autoimmune disease that results in patches of depigmented skin and hair. Previous genome-wide association studies (GWASs) of vitiligo have identified 50 susceptibility loci. Variants at the associated loci are generally common and have individually small effects on risk. Most vitiligo cases are “simplex,” where there is no family history of vitiligo, though occasional family clustering of vitiligo occurs, and some “multiplex”...
Paper Details
Title
Family Clustering of Autoimmune Vitiligo Results Principally from Polygenic Inheritance of Common Risk Alleles
Published Date
Aug 1, 2019
Volume
105
Issue
2
Pages
364 - 372
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