Molecular basis of tRNA recognition by the Elongator complex
Abstract
The highly conserved Elongator complex modifies transfer RNAs (tRNAs) in their wobble base position, thereby regulating protein synthesis and ensuring proteome stability. The precise mechanisms of tRNA recognition and its modification reaction remain elusive. Here, we show cryo-electron microscopy structures of the catalytic subcomplex of Elongator and its tRNA-bound state at resolutions of 3.3 and 4.4 Å. The structures resolve details of the...
Paper Details
Title
Molecular basis of tRNA recognition by the Elongator complex
Published Date
Jul 5, 2019
Journal
Volume
5
Issue
7
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