Epigenetic reprogramming of primary pancreatic cancer cells counteracts their in vivo tumourigenicity
Abstract
Pancreatic ductal adenocarcinoma (PDAC) arises through accumulation of multiple genetic alterations. However, cancer cells also acquire and depend on cancer-specific epigenetic changes. To conclusively demonstrate the crucial relevance of the epigenetic programme for the tumourigenicity of the cancer cells, we used cellular reprogramming technology to reverse these epigenetic changes. We reprogrammed human PDAC cultures using three different...
Paper Details
Title
Epigenetic reprogramming of primary pancreatic cancer cells counteracts their in vivo tumourigenicity
Published Date
Jul 15, 2019
Journal
Volume
38
Issue
34
Pages
6226 - 6239
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