BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle

Significance The brain-derived neurotrophic factor (BDNF) is essential to promote neuronal differentiation, plasticity, and survival. Altered BDNF expression is associated with several pathologies, including neuropsychiatric and neurodegenerative disorders, cardiovascular diseases, diabetes, and motor neuron diseases. Although BDNF has been identified as a contraction-induced myokine, its involvement in muscle physiology is unclear. Using...