Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

Pages: 682013
Published: Jul 10, 2019
Abstract
null Heart failure (HF) is a leading cause of morbidity and mortality worldwide1. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained2–4. We report the largest GWAS meta-analysis of HF to-date, comprising 47,309 cases and 930,014 controls. We identify 12 independent variant...
Paper Details
Title
Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure
Published Date
Jul 10, 2019
Journal
Pages
682013
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