Cleavage stage mitochondrial DNA is correlated with preimplantation human embryo development and ploidy status

To evaluate whether the mitoscore of cleavage stage embryos might correlate with developmental kinetics and the ploidy status.This retrospective single-center study involved all cycles between April 2016 and April 2018 in which preimplantation genetic testing for aneuploidy (PGT-A) on day 3 was performed. The mitochondrial DNA (mtDNA) content and embryo ploidy were determined on 375 single blastomere biopsies by next generation sequencing (NGS)....