Design, Synthesis and Docking Calculations of Prenylated Chalcones as Selective Monoamine Oxidase B Inhibitors with Antioxidant Activity

Different natural and synthetic chalcones have exhibited selective inhibition on monoamine oxidase B (MAO−B) activity, demonstrating potential interest for the treatment of neurodegenerative diseases. Herein we report the synthesis of seven new prenylated chalcones (7a‐g) obtained from the natural compound 5 (4‐hydroxy‐3‐(3‐methylbut‐2‐en‐1‐yl)phenylethanone), previously isolated from S. graveolens . Five of these compounds exhibit high...