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Functional connectivity of brain associated with passive range of motion exercise: Proprioceptive input promoting motor activation?

Published on Jul 17, 2019in NeuroImage 5.81
· DOI :10.1016/j.neuroimage.2019.116023
Fatima A. Nasrallah14
Estimated H-index: 14
(UQ: University of Queensland),
Abdalla Z. Mohamed1
Estimated H-index: 1
(UQ: University of Queensland)
+ 3 AuthorsJeong Hoon Lim7
Estimated H-index: 7
(NUS: National University of Singapore)
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Abstract
Abstract Soft robotics have come to the forefront of devices available for rehabilitation following stroke; however, objective evaluation of the specific brain changes following rehabilitation with these devices is lacking. In this study, we utilized functional Magnetic Resonance Imaging (fMRI) and dynamic causal modeling (DCM) to characterize the activation of brain areas with a MRI compatible glove actuator compared to the conventional manual therapy. Thirteen healthy volunteers engaged in a motor-visual fMRI task under four different conditions namely active movement, manual passive movement, passive movement using a glove actuator, and crude tactile stimulation. Brain activity following each task clearly identified the somatosensory motor area (SMA) as a major hub orchestrating activity between the primary motor (M1) and sensory (S1) cortex. During the glove-induced passive movement, activity in the motor-somatosensory areas was reduced, but there were significant increases in motor cortical activity compared to manual passive movement. We estimated the modulatory signaling from within a defined sensorimotor network (SMA, M1, and S1), through DCM and highlighted a dual-gating of sensorimotor inputs to the SMA. Proprioceptive signaling from S1 to the SMA reflected positive coupling for the manually assisted condition, while M1 activity was positively coupled to the SMA during the glove condition. Importantly, both the S1 and M1 were shown to influence each other's connections with the SMA, with inhibitory nonlinear modulation by the M1 on the S1-SMA connection, and similarly S1 gated the M1-SMA connection. The work is one of the first to have applied effective connectivity to examine sensorimotor activity ensued by manual or robotic passive range of motion exercise, crude tactile stimulation, and voluntary movements to provide a basis for the mechanism by which soft actuators can alter brain activity.
  • References (47)
  • Citations (0)
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References47
Newest
Published on Oct 15, 2018in PLOS ONE 2.78
Sasha Blue Godfrey11
Estimated H-index: 11
(IIT: Istituto Italiano di Tecnologia),
Kristin D Zhao24
Estimated H-index: 24
+ 9 AuthorsMarco Santello30
Estimated H-index: 30
Published on Jun 18, 2018in Actuators
Tapio V. J. Tarvainen2
Estimated H-index: 2
,
Jacobo Fernandez-Vargas2
Estimated H-index: 2
,
Wenwei Yu15
Estimated H-index: 15
Fiber-reinforced fluid-driven elastomer actuators have enabled the production of simple, low-cost and safe hand rehabilitation devices. However, so far, the actuators support only finger flexion-extension, and little has been reported on abduction-adduction, which is essential for manipulation tasks and grasping larger objects. The technical design difficulty of realizing abduction-adduction lies in the suppression of interference effects between the metacarpophalangeal (MCP) joint’s two orthogo...
Published on Oct 25, 2017in Frontiers in Neuroscience 3.65
Tze Hui Koh2
Estimated H-index: 2
(NUS: National University of Singapore),
Nicholas Cheng2
Estimated H-index: 2
(NUS: National University of Singapore)
+ 1 AuthorsChen-Hua Yeow15
Estimated H-index: 15
(NUS: National University of Singapore)
The provision of continuous passive, and intent-based assisted movements for neuromuscular training can be incorporated into a robotic elbow sleeve. The objective of this study is to propose the design and test the functionality of a soft robotic elbow sleeve in assisting flexion and extension of the elbow, both passively and using intent-based motion reinforcement. First, the elbow sleeve was developed, using elastomeric and fabric-based pneumatic actuators, which are soft and lightweight, in o...
Hong Kai Yap8
Estimated H-index: 8
(NUS: National University of Singapore),
Nazir Kamaldin4
Estimated H-index: 4
(NUS: National University of Singapore)
+ 3 AuthorsChen-Hua Yeow15
Estimated H-index: 15
(NUS: National University of Singapore)
In this paper, we present the design, fabrication and evaluation of a soft wearable robotic glove, which can be used with functional Magnetic Resonance imaging (fMRI) during the hand rehabilitation and task specific training. The soft wearable robotic glove, called MR-Glove, consists of two major components: a) a set of soft pneumatic actuators and b) a glove. The soft pneumatic actuators, which are made of silicone elastomers, generate bending motion and actuate finger joints upon pressurizatio...
Published on Aug 21, 2016
Mahdi Haghshenas-Jaryani5
Estimated H-index: 5
(UTA: University of Texas at Arlington),
Wei Carrigan2
Estimated H-index: 2
(UTA: University of Texas at Arlington)
+ 3 AuthorsTimothy Niacaris2
Estimated H-index: 2
(University of North Texas Health Science Center)
Published on Jan 4, 2016in Cerebral Cortex 5.44
Fabien Cignetti11
Estimated H-index: 11
,
Aurelie Fontan2
Estimated H-index: 2
+ 4 AuthorsChristine Assaiante28
Estimated H-index: 28
Proprioceptive processing is important for appropriate motor control, providing error-feedback and internal representation of movement for adjusting the motor command. Although proprioceptive functioning improves during childhood and adolescence, we still have few clues about how the proprioceptive brain network develops. Here, we investigated developmental changes in the functional organization of this network in early adolescents (n = 18, 12 ± 1 years), late adolescents (n = 18, 15 ± 1), and y...
Published on Jun 4, 2015in Frontiers in Human Neuroscience 2.87
Avisa Asemi1
Estimated H-index: 1
(Center for Complex Systems and Brain Sciences),
Karthik Ramaseshan5
Estimated H-index: 5
(WSU: Wayne State University)
+ 2 AuthorsSteven L. Bressler47
Estimated H-index: 47
(Center for Complex Systems and Brain Sciences)
Motor control is integral to all types of human behavior, and the dorsal Anterior Cingulate Cortex (dACC) is thought to play an important role in the brain network underlying motor control. Yet the role of the dACC in motor control is under-characterized. Here we aimed to characterize the dACC’s role in adolescent brain network interactions during a simple motor control task involving visually coordinated unimanual finger movements. Network interactions were assessed using both undirected and di...
Published on Nov 28, 2014in Frontiers in Human Neuroscience 2.87
Adriaan R. E. Potgieser4
Estimated H-index: 4
(UMCG: University Medical Center Groningen),
de Bauke Jong1
Estimated H-index: 1
(UMCG: University Medical Center Groningen)
+ 2 AuthorsRob J. M. Groen22
Estimated H-index: 22
(UMCG: University Medical Center Groningen)
The supplementary motor area syndrome is a characteristic neurosurgical syndrome that can occur after unilateral resection of the supplementary motor area. Clinical symptoms may vary from none to a global akinesia, predominantly on the contralateral side, with preserved muscle strength, and mutism. A remarkable feature is that these symptoms completely resolve within weeks to months, leaving only a disturbance in alternating bimanual movements. In this review we give an overview of the old and n...
Published on May 1, 2014in NeuroImage 5.81
Marta Gandolla9
Estimated H-index: 9
(Polytechnic University of Milan),
Simona Ferrante20
Estimated H-index: 20
(Polytechnic University of Milan)
+ 7 AuthorsNick S. Ward42
Estimated H-index: 42
(UCL Institute of Neurology)
The standard account of motor control considers descending outputs from primary motor cortex (M1) as motor commands and efference copy. This account has been challenged recently by an alternative formulation in terms of active inference: M1 is considered as part of a sensorimotor hierarchy providing top–down proprioceptive predictions. The key difference between these accounts is that predictions are sensitive to the current proprioceptive context, whereas efference copy is not. Using functional...
Published on Mar 1, 2014in Neuroscience 3.24
Lele Xu9
Estimated H-index: 9
(BNU: Beijing Normal University),
Hui Zhang10
Estimated H-index: 10
(CAS: Chinese Academy of Sciences)
+ 4 AuthorsLi Yao19
Estimated H-index: 19
(BNU: Beijing Normal University)
Abstract Motor execution and imagery (ME and MI), as the basic abilities of human beings, have been considered to be effective strategies in motor skill learning and motor abilities rehabilitation. Neuroimaging studies have revealed several critical regions from functional activation for ME as well as MI. Recently, investigations have probed into functional connectivity of ME; however, few explorations compared the functional connectivity between the two tasks. With betweenness centrality (BC) o...
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