Samidorphan mitigates olanzapine-induced weight gain and metabolic dysfunction in rats and non-human primates
Abstract
Background: Olanzapine, regarded as one of the most efficacious antipsychotic medications for the treatment of schizophrenia, is associated with a high risk of weight gain and metabolic dysfunction. ALKS 3831, a clinical candidate for treatment of schizophrenia, is a combination of olanzapine and samidorphan, an opioid receptor antagonist. The addition of samidorphan is intended to mitigate weight gain and the metabolic dysregulation associated...
Paper Details
Title
Samidorphan mitigates olanzapine-induced weight gain and metabolic dysfunction in rats and non-human primates
Published Date
Jul 11, 2019
Volume
33
Issue
10
Pages
1303 - 1316
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