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Nature beyond control: how expectations should inform decisions about human germline engineering

Published on Jul 16, 2019in Journal of Assisted Reproduction and Genetics 2.79
· DOI :10.1007/s10815-019-01528-4
Abstract
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References23
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Published on Apr 30, 2019in PLOS Biology 9.16
Arthur Caplan19
Estimated H-index: 19
(NYU: New York University)
The announcement of He Jiankui’s germline editing of human embryos has been followed by a torrent of almost universal criticism of the claim on scientific and ethical grounds. That criticism is warranted. There is little room for anything other than vociferous condemnation of He's announcement. Presenting the results of groundbreaking work by press conference and YouTube is not science. The issue now is not whether the work supporting the claims reported from China was done in an ethical manner....
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Published on Dec 1, 2018in Nature Communications 12.35
Jean-Louis Guéant47
Estimated H-index: 47
(University of Lorraine),
Céline Chéry11
Estimated H-index: 11
(University of Lorraine)
+ 28 AuthorsIsabelle Gastin2
Estimated H-index: 2
(University of Lorraine)
To date, epimutations reported in man have been somatic and erased in germlines. Here, we identify a cause of the autosomal recessive cblC class of inborn errors of vitamin B12 metabolism that we name “epi-cblC”. The subjects are compound heterozygotes for a genetic mutation and for a promoter epimutation, detected in blood, fibroblasts, and sperm, at the MMACHC locus; 5-azacytidine restores the expression of MMACHC in fibroblasts. MMACHC is flanked by CCDC163P and PRDX1, which are in the opposi...
8 Citations Source Cite
Published on Aug 1, 2017in Nature 41.58
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Nuria Marti-Gutierrez1
Estimated H-index: 1
(OHSU: Oregon Health & Science University)
+ 28 AuthorsRiffat Ahmed10
Estimated H-index: 10
(OHSU: Oregon Health & Science University)
CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.
259 Citations Source Cite
Published on Jan 1, 2017in Cell 31.40
Benjamin J. Rauch5
Estimated H-index: 5
(UCSF: University of California, San Francisco),
Melanie R. Silvis3
Estimated H-index: 3
(UCSF: University of California, San Francisco)
+ 4 AuthorsJoseph Bondy-Denomy19
Estimated H-index: 19
(UCSF: University of California, San Francisco)
Summary Bacterial CRISPR-Cas systems utilize sequence-specific RNA-guided nucleases to defend against bacteriophage infection. As a countermeasure, numerous phages are known that produce proteins to block the function of class 1 CRISPR-Cas systems. However, currently no proteins are known to inhibit the widely used class 2 CRISPR-Cas9 system. To find these inhibitors, we searched cas9 -containing bacterial genomes for the co-existence of a CRISPR spacer and its target, a potential indicator for ...
116 Citations Source Cite
Published on Nov 1, 2015in EMBO Reports 8.75
Arthur Caplan19
Estimated H-index: 19
(NYU: New York University),
Brendan Parent3
Estimated H-index: 3
(NYU: New York University)
+ 1 AuthorsCarolyn Plunkett3
Estimated H-index: 3
(NYU: New York University)
The term “CRISPR” has gained a lot of attention recently as a result of a debate among scientists about the possibility of genetically modifying the human germ line and the ethical implications of doing so. However, CRISPR is not just a method to edit the genomes of embryonic cells, as the public discussion might have implied; it is a powerful, efficient, and reliable tool for editing genes in any organism, and it has garnered significant attention and use among biologists for a variety of purpo...
34 Citations Source Cite
Published on May 1, 2015in Protein & Cell 6.23
Puping Liang7
Estimated H-index: 7
(SYSU: Sun Yat-sen University),
Yanwen Xu14
Estimated H-index: 14
(SYSU: Sun Yat-sen University)
+ 13 AuthorsYujing Li10
Estimated H-index: 10
(SYSU: Sun Yat-sen University)
Genome editing tools such as the clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) have been widely used to modify genes in model systems including animal zygotes and human cells, and hold tremendous promise for both basic research and clinical applications. To date, a serious knowledge gap remains in our understanding of DNA repair mechanisms in human early embryos, and in the efficiency and potential off-target effects of using technologies such as CRISP...
458 Citations Source Cite
Published on Mar 1, 2015in Nature Biotechnology 35.72
Jacob S. Sherkow7
Estimated H-index: 7
(New York Law School)
Predicting the outcome of the ongoing patent disputes surrounding genome-editing technology is equal parts patent analysis and history.
18 Citations Source Cite
Kelly E. Cichy11
Estimated H-index: 11
(KSU: Kent State University),
Eva S. Lefkowitz30
Estimated H-index: 30
(PSU: Pennsylvania State University)
+ 1 AuthorsKaren L. Fingerman33
Estimated H-index: 33
(University of Texas at Austin)
Objectives. Parents’ perceptions of their adult children’s successes (or lack thereof) may be associated in different ways with discrete negative emotions (e.g., guilt, anger, disappointment, and worry). Furthermore, mothers and fathers may vary in their reactions to children’s success in different domains. Method. Participants included 158 mothers and fathers from the same families (N = 316) and their adult child. Mothers and fathers evaluated their adult children’s successes in (a) career and ...
8 Citations Source Cite
Published on Aug 31, 2013in Annual Review of Genomics and Human Genetics 8.68
Denise Lautenbach7
Estimated H-index: 7
(Harvard University),
Kurt D. Christensen18
Estimated H-index: 18
(Harvard University)
+ 1 AuthorsRobert C. Green67
Estimated H-index: 67
(Harvard University)
Communicating genetic risk information in ways that maximize understanding and promote health is increasingly important given the rapidly expanding availability and capabilities of genomic technologies. A well-developed literature on risk communication in general provides guidance for best practices, including presentation of information in multiple formats, attention to framing effects, use of graphics, sensitivity to the way numbers are presented, parsimony of information, attentiveness to emo...
68 Citations Source Cite
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