Cholesterol and 27-hydroxycholesterol promote thyroid carcinoma aggressiveness

Giovanna Revilla; Monica de Pablo Pons; Lucía Baila-Rueda; Annabel García-León; David Santos; Ana Cenarro; Marcelo Magalhães; Roman Blanco; Antonio Moral; Jose Ignacio Arias Perez; Joan Carles Escolà-Gil; Eugenia Mato

doi:https://doi.org/10.1038/s41598-019-46727-2

doi.org/10.1038/s41598-019-46727-2

Cholesterol and 27-hydroxycholesterol promote thyroid carcinoma aggressiveness

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..., Eugenia Mato

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Scientific Reports4.60

Volume: 9, Issue: 1

Published: Jul 16, 2019

Abstract

Cholesterol mediates its proliferative and metastatic effects via the metabolite 27-hydroxycholesterol (27-HC), at least in breast and endometrial cancer. We determined the serum lipoprotein profile, intratumoral cholesterol and 27-HC levels in a cohort of patients with well-differentiated papillary thyroid carcinoma (PTC; low/intermediate and high risk), advanced thyroid cancers (poorly differentiated, PDTC and anaplastic thyroid carcinoma,...

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Paper Details

Title

Cholesterol and 27-hydroxycholesterol promote thyroid carcinoma aggressiveness

DOI

doi.org/10.1038/s41598-019-46727-2

Published Date

Jul 16, 2019

Journal

Scientific Reports

Volume

9

Issue

1

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