Structures of single‐layer β‐sheet proteins evolved from β‐hairpin repeats
Abstract
Free‐standing single‐layer β‐sheets are extremely rare in naturally occurring proteins, even though β‐sheet motifs are ubiquitous. Here we report the crystal structures of three homologous, single‐layer, anti‐parallel β‐sheet proteins, comprised of three or four twisted β‐hairpin repeats. The structures reveal that, in addition to the hydrogen bond network characteristic of β‐sheets, additional hydrophobic interactions mediated by small clusters...
Paper Details
Title
Structures of single‐layer β‐sheet proteins evolved from β‐hairpin repeats
Published Date
Aug 2, 2019
Journal
Volume
28
Issue
9
Pages
1676 - 1689
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