Effects of Amylin Against Amyloid-β-Induced Tauopathy and Synapse Loss in Primary Neurons
Abstract
Recent studies demonstrate that peripheral amylin treatment reduces pathology in mouse models of Alzheimer's disease (AD). However, soluble and aggregated amylin are distinct species; while amylin is a physiological neuropeptide, amylin aggregation is a pathological factor for diabetes. We thus hypothesized that because of their similarity in secondary structures, amylin antagonizes amyloid-β peptide (Aβ)-induced AD pathology in neurons with a...
Paper Details
Title
Effects of Amylin Against Amyloid-β-Induced Tauopathy and Synapse Loss in Primary Neurons
Published Date
Aug 20, 2019
Volume
70
Issue
4
Pages
1025 - 1040
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