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Published on Dec 1, 2018in Immunity 21.52
Abdul Malik Tyagi5
Estimated H-index: 5
(Emory University),
Mingcan Yu4
Estimated H-index: 4
(Emory University)
+ 8 AuthorsRheinallt M. Jones20
Estimated H-index: 20
(Emory University)
Summary Nutritional supplementation with probiotics can prevent pathologic bone loss. Here we examined the impact of supplementation with Lactobacillus rhamnosus GG (LGG) on bone homeostasis in eugonadic young mice. Micro-computed tomography revealed that LGG increased trabecular bone volume in mice, which was due to increased bone formation. Butyrate produced in the gut following LGG ingestion, or butyrate fed directly to germ-free mice, induced the expansion of intestinal and bone marrow (BM) ...
Published on Dec 1, 2018in Nature Communications 11.88
Sébastien Lucas2
Estimated H-index: 2
(FAU: University of Erlangen-Nuremberg),
Yasunori Omata2
Estimated H-index: 2
(FAU: University of Erlangen-Nuremberg)
+ 12 AuthorsGerhard Kroenke28
Estimated H-index: 28
(FAU: University of Erlangen-Nuremberg)
Microbial metabolites are known to modulate immune responses of the host. The main metabolites derived from microbial fermentation of dietary fibers in the intestine, short-chain fatty acids (SCFA), affect local and systemic immune functions. Here we show that SCFA are regulators of osteoclast metabolism and bone mass in vivo. Treatment of mice with SCFA as well as feeding with a high-fiber diet significantly increases bone mass and prevents postmenopausal and inflammation-induced bone loss. The...
Published on Dec 1, 2018in Scientific Reports 4.01
Ravinder Nagpal4
Estimated H-index: 4
(Wake Forest University),
Shaohua Wang2
Estimated H-index: 2
(Wake Forest University)
+ 7 AuthorsHariom Yadav23
Estimated H-index: 23
(Wake Forest University)
The gut bacteria producing metabolites like short-chain fatty acids (SCFAs; e.g., acetate, propionate and butyrate), are frequently reduced in Patients with diabetes, obesity, autoimmune disorders, and cancers. Hence, microbiome modulators such as probiotics may be helpful in maintaining or even restoring normal gut microbiome composition to benefit host health. Herein, we developed a human-origin probiotic cocktail with the ability to modulate gut microbiota to increase native SCFA production. ...
Published on Dec 1, 2018in Nature Communications 11.88
Rachel Fellows1
Estimated H-index: 1
(Babraham Institute),
Jérémy Denizot9
Estimated H-index: 9
(Babraham Institute)
+ 23 AuthorsJuri Kazakevych1
Estimated H-index: 1
(Babraham Institute)
The recently discovered histone post-translational modification crotonylation connects cellular metabolism to gene regulation. Its regulation and tissue-specific functions are poorly understood. We characterize histone crotonylation in intestinal epithelia and find that histone H3 crotonylation at lysine 18 is a surprisingly abundant modification in the small intestine crypt and colon, and is linked to gene regulation. We show that this modification is highly dynamic and regulated during the cel...
Published on Dec 1, 2018in Scientific Reports 4.01
Yu Tahara20
Estimated H-index: 20
(Waseda University),
Mayu Yamazaki2
Estimated H-index: 2
(Waseda University)
+ 7 AuthorsShigenobushibata54
Estimated H-index: 54
(Waseda University)
Microbiota-derived short-chain fatty acids (SCFAs) and organic acids produced by the fermentation of non-digestible fibre can communicate from the microbiome to host tissues and modulate homeostasis in mammals. The microbiome has circadian rhythmicity and helps the host circadian clock function. We investigated the effect of SCFA or fibre-containing diets on circadian clock phase adjustment in mouse peripheral tissues (liver, kidney, and submandibular gland). Initially, caecal SCFA concentration...
Published on Sep 1, 2018in Journal of Internal Medicine 6.05
Anna Nilsson16
Estimated H-index: 16
(University of Gothenburg),
Daniel Sundh10
Estimated H-index: 10
(University of Gothenburg)
+ 1 AuthorsMattias Lorentzon50
Estimated H-index: 50
(University of Gothenburg)
Published on Jul 6, 2018in Frontiers in Immunology 4.72
Da Som Kim2
Estimated H-index: 2
(Catholic University of Korea),
Jeong-Eun Kwon4
Estimated H-index: 4
(Catholic University of Korea)
+ 9 AuthorsSung-Hwan Park36
Estimated H-index: 36
(Catholic University of Korea)
Rheumatoid arthritis (RA) is a systemic autoimmune disease caused by both genetic and environmental factors. Recently, investigators have focused on the gut microbiota, which is thought to be an environmental factor that affects the development of RA. Metabolites secreted by the gut microbiota maintain homeostasis in the gut through various mechanisms (e.g., butyrate, which is one of the major metabolites of gut microbiota, exerts an anti-inflammatory effect by activating G-protein-coupled recep...
Published on Jan 1, 2018in EMBO Reports 8.38
Mingcan Yu4
Estimated H-index: 4
(Emory University),
Patrizia D'Amelio14
Estimated H-index: 14
(UNITO: University of Turin)
+ 9 AuthorsM. Neale Weitzmann32
Estimated H-index: 32
(Emory University)
Abstract Teriparatide is a bone anabolic treatment for osteoporosis, modeled in animals by intermittent PTH (iPTH) administration, but the cellular and molecular mechanisms of action of iPTH are largely unknown. Here, we show that Teriparatide and iPTH cause a ~two‐threefold increase in the number of regulatory T cells (Tregs) in humans and mice. Attesting in vivo relevance, blockade of the Treg increase in mice prevents the increase in bone formation and trabecular bone volume and structure ind...
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