Shared roles for Scl and Lyl1 in murine platelet production and function
Abstract
The stem cell leukemia (Scl or Tal1) protein forms part of a multimeric transcription factor complex required for normal megakaryopoiesis. However, unlike other members of this complex such as Gata1, Fli1, and Runx1, mutations of Scl have not been observed as a cause of inherited thrombocytopenia. We postulated that functional redundancy with its closely related family member, lymphoblastic leukemia 1 (Lyl1) might explain this observation. To...
Paper Details
Title
Shared roles for Scl and Lyl1 in murine platelet production and function
Published Date
Sep 5, 2019
Journal
Volume
134
Issue
10
Pages
826 - 835
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