Structural basis for the ORC1‐Cyclin A association
Abstract
Progression of cell cycle is regulated by sequential expression of cyclins, which associate with distinct cyclin kinases to drive the transition between different cell cycle phases. The complex of Cyclin A with cyclin‐dependent kinase 2 (CDK2) controls the DNA replication activity through phosphorylation of a set of chromatin factors, which critically influences the S phase transition. It has been shown that the direct interaction between the...
Paper Details
Title
Structural basis for the ORC1‐Cyclin A association
Published Date
Jul 31, 2019
Journal
Volume
28
Issue
9
Pages
1727 - 1733
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Notes
History