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doi.org/10.1016/j.stem.2019.06.007

Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging

..., Simón Méndez-Ferrer
35
Cell Stem Cell23.90
Volume: 25, Issue: 3, Pages: 407 - 418.e6
Published: Sep 1, 2019
Abstract
Hematopoietic stem cells (HSCs) residing in the bone marrow (BM) accumulate during aging but are functionally impaired. However, the role of HSC-intrinsic and -extrinsic aging mechanisms remains debated. Megakaryocytes promote quiescence of neighboring HSCs. Nonetheless, whether megakaryocyte-HSC interactions change during pathological/natural aging is unclear. Premature aging in Hutchinson-Gilford progeria syndrome recapitulates physiological...
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Paper Details
Title
Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging
DOI
doi.org/10.1016/j.stem.2019.06.007
Published Date
Sep 1, 2019
Journal
Cell Stem Cell
Volume
25
Issue
3
Pages
407 - 418.e6
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