Functional divergence caused by mutations in an energetic hotspot in ERK2

Volume: 116, Issue: 31, Pages: 15514 - 15523
Published: Jul 30, 2019
Abstract
The most frequent extracellular signal-regulated kinase 2 (ERK2) mutation occurring in cancers is E322K (E-K). ERK2 E-K reverses a buried charge in the ERK2 common docking (CD) site, a region that binds activators, inhibitors, and substrates. Little is known about the cellular consequences associated with this mutation, other than apparent increases in tumor resistance to pathway inhibitors. ERK2 E-K, like the mutation of the preceding aspartate...
Paper Details
Title
Functional divergence caused by mutations in an energetic hotspot in ERK2
Published Date
Jul 30, 2019
Volume
116
Issue
31
Pages
15514 - 15523
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