Templated Insertions: A Smoking Gun for Polymerase Theta-Mediated End Joining
Abstract
A recognized source of disease-causing genome alterations is erroneous repair of broken chromosomes, which can be executed by two distinct mechanisms: non-homologous end joining (NHEJ) and the recently discovered polymerase theta-mediated end joining (TMEJ) pathway. While TMEJ has previously been considered to act as an alternative mechanism backing up NHEJ, recent work points to a role for TMEJ in the repair of replication-associated DNA breaks...
Paper Details
Title
Templated Insertions: A Smoking Gun for Polymerase Theta-Mediated End Joining
Published Date
Sep 1, 2019
Journal
Volume
35
Issue
9
Pages
632 - 644
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