Opening TRPP2 ( PKD2L1 ) requires the transfer of gating charges

Significance Dysfunction of polycystin TRP channels (TRPPs) is associated with polycystic kidney disease (PKD), but their biophysical and structural regulation is poorly understood. We report that TRPP2 voltage sensor activation is required to open the conducting pore, regardless of polymodal stimuli. Each of the 4 voltage sensor domains delivers at least 1 gating charge prior to TRPP2 channel opening while forming state-dependent cation–π...