Circular zymogens of human ribonuclease 1
Abstract
The endogenous production of enzymes as zymogens provides a means to control catalytic activities. Here, we describe the heterologous production of ribonuclease 1 (RNase 1), which is the most prevalent secretory ribonuclease in humans, as a zymogen. In folded RNase 1, the N and C termini flank the enzymic active site. By using intein‐mediated cis‐splicing, we created circular proteins in which access to the active site of RNase 1 is obstructed...
Paper Details
Title
Circular zymogens of human ribonuclease 1
Published Date
Aug 6, 2019
Journal
Volume
28
Issue
9
Pages
1713 - 1719
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