Time-course pattern of neuronal death and gliosis in gerbil hippocampi induced by mild, severe and lethal transient global cerebral ischemia

Background: Transient ischemia (TI) in whole brain brings selective neuronal death in vulnerable areas of the brain: the striatum, neocortex and hippocampus selectively loose specific neurons after TI. Just 5 min of TI causes pyramidal neuronal death in the hippocampal CA1 field (CA1) from 4 days after TI. In this study, we examined the impact of severity of TI on neuronal death and gliosis (astrocytosis and microgliosis) in subregions (CA1-3...