Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis
Abstract
Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. By performing RNA sequencing in livers from patients with different phenotypes of alcohol-related liver disease (ALD), we show that development of AH is characterized by defective activity of...
Paper Details
Title
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis
Published Date
Jul 16, 2019
Journal
Volume
10
Issue
1
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