PIPAC paclitaxel: A systematic and peritoneal tissue pharmacokinetic study in swine

Introduction: Peritoneal carcinomatosis is a distressing disease with current standard palliative chemotherapy typically producing disappointing results. PIPAC is an innovative method of delivering chemotherapy directly to the peritoneum, aiming to achieve a homogenous and deeper drug penetration. To date, most trials use cisplatin with doxorubicin, or oxaliplatin alone with promising results. We aim to evaluate the pharmacokinetics (PK) and...