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Neutrophil extracellular traps generation and degradation in patients with granulomatosis with polyangiitis and systemic lupus erythematosus

Published on Apr 3, 2019in Autoimmunity2.403
· DOI :10.1080/08916934.2019.1631812
Michal Przemyslaw Pruchniak6
Estimated H-index: 6
(Medical University of Warsaw),
Magdalena Ostafin3
Estimated H-index: 3
(Medical University of Warsaw)
+ 5 AuthorsUrszula Demkow20
Estimated H-index: 20
(Medical University of Warsaw)
Abstract
AbstractNeutrophils are one of the first cells to arrive at the site of infection, where they apply several strategies to kill pathogens: degranulation, respiratory burst, phagocytosis, and release...
  • References (78)
  • Citations (1)
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References78
Newest
#1Sebastian Boeltz (FAU: University of Erlangen-Nuremberg)H-Index: 7
#2Poorya Amini (University of Bern)H-Index: 6
Last. Martin Herrmann (FAU: University of Erlangen-Nuremberg)H-Index: 65
view all 49 authors...
Since the discovery and definition of neutrophil extracellular traps (NETs) 14 years ago, numerous characteristics and physiological functions of NETs have been uncovered. Nowadays, the field continues to expand and novel mechanisms that orchestrate formation of NETs, their previously unknown properties, and novel implications in disease continue to emerge. The abundance of available data has also led to some confusion in the NET research community due to contradictory results and divergent scie...
26 CitationsSource
#1Daniel Appelgren (Linköping University)H-Index: 1
#2Charlotte Dahle (Linköping University)H-Index: 20
Last. Christopher Sjöwall (Linköping University)H-Index: 22
view all 12 authors...
Although neutrophil extracellular traps (NETs) have been highlighted in several systemic inflammatory diseases, their clinical correlates and potential pathological role remain obscure. Herein, we describe a dramatic onset of systemic lupus erythematosus (SLE) with clear-cut pathogenic implications for neutrophils and NET formation in a young woman with cardiac (Libman–Sacks endocarditis) and central nervous system (psychosis and seizures) involvement. Despite extensive search, circulating antip...
2 CitationsSource
#1Robert D. Gray (Edin.: University of Edinburgh)H-Index: 16
#2G. Hardisty (Edin.: University of Edinburgh)H-Index: 2
Last. Donald J. Davidson (Edin.: University of Edinburgh)H-Index: 39
view all 22 authors...
Background Cystic fibrosis (CF) lung disease is defined by large numbers of neutrophils and associated damaging products in the airway. Delayed neutrophil apoptosis is described in CF although it is unclear whether this is a primary neutrophil defect or a response to chronic inflammation. Increased levels of neutrophil extracellular traps (NETs) have been measured in CF and we aimed to investigate the causal relationship between these phenomena and their potential to serve as a driver of inflamm...
25 CitationsSource
#1Cristiane Naffah de Souza (USP: University of São Paulo)H-Index: 1
#2Leandro C. D. Breda (USP: University of São Paulo)H-Index: 1
Last. Nades Palaniyar (U of T: University of Toronto)H-Index: 29
view all 7 authors...
pH is highly variable in different tissues, and affects many enzymatic reactions in neutrophils. In response to calcium ionophores such as A23187 and ionomycin, neutrophils undergo nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX)-independent neutrophil extracellular trap (NET) formation (NETosis). However, how pH influences the calcium-dependent Nox-independent NET formation is not well understood. We hypothesized that increasing pH promotes Nox-independent NET formation by prom...
16 CitationsSource
#1Liliang Jin (LSU: Louisiana State University)H-Index: 4
#2Sanjay Batra (LSU: Louisiana State University)H-Index: 34
Last. Samithamby Jeyaseelan (LSU Health Sciences Center New Orleans)H-Index: 21
view all 3 authors...
Polymicrobial sepsis is the result of an exaggerated host immune response to bacterial pathogens. Animal models and human studies demonstrate that alcohol intoxication is a key risk factor for sepsis-induced mortality. Multiple chemokines, such as CXCL1, CXCL2 and CXCL5 are critical for neutrophil recruitment and proper function of neutrophils. However, it is not quite clear the mechanisms by which acute alcohol suppresses immune responses and whether alcohol-induced immunosuppression can be res...
8 CitationsSource
#1Rachita Panda (UHH: University of Hamburg)H-Index: 5
#2Thorsten Krieger (UHH: University of Hamburg)H-Index: 8
Last. Tobias A. Fuchs (KI: Karolinska Institutet)H-Index: 27
view all 9 authors...
Neutrophil extracellular traps (NETs) are chromatin filaments decorated with enzymes from neutrophil cytoplasmic granules. Anti-neutrophil cytoplasmic antibodies (ANCAs) bind to enzymes from neutrophil cytoplasmic granules and are biomarkers for the diagnosis of systemic vasculitides. ANCA-diagnostics are based on indirect immunofluorescence (IIF) of ethanol-fixed neutrophils. IIF shows a cytoplasmic staining pattern (C-ANCA) due to autoantibodies against proteinase 3 (PR3) or a perinuclear stai...
12 CitationsSource
#1Vidal Delgado-Rizo (University of Guadalajara)H-Index: 10
#2Marco Alonso Martinez-Guzman (University of Guadalajara)H-Index: 1
Last. Mary Fafutis-Morris (University of Guadalajara)H-Index: 10
view all 6 authors...
In addition to physical barriers, neutrophils are considered a part of the first line of immune defense. They can be found in the bloodstream, with a lifespan of 6-8 hours, and in tissue, where they can last up to seven days. The mechanisms that neutrophils utilize for host defense are phagocytosis, degranulation, cytokine production and, the most recently described, neutrophil extracellular trap (NET) production. NETs are DNA structures released due to chromatin decondensation and spreading, an...
104 CitationsSource
#1Åsa Johansson (Lund University)H-Index: 15
#2Sophie Ohlsson (Lund University)H-Index: 12
Last. Thomas Hellmark (Lund University)H-Index: 28
view all 7 authors...
Background Anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) is a group of autoimmune diseases, characterized by small vessel inflammation. Phagocytes such as neutrophils and monocytes are the main effector cells found around the inflamed vessel wall. Therefore, we wanted to investigate aspects of function and activation of these cells in patients with AAV.
5 CitationsSource
#1Stavros GiaglisH-Index: 16
#2Sinuhe HahnH-Index: 52
Last. Paul HaslerH-Index: 12
view all 3 authors...
Neutrophil extracellular trap (NET) formation represents a form of cell death distinct from apoptosis or necrosis, by which invading pathogens are simultaneously entangled and potentially eliminated. Increased NET formation is observed in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), antineutrophil cytoplasmic antibody (ANCA)-associated and small vessel vasculitis (SVV), antiphospholipid antibody syndrome (APS) and psoriasis. NETs contribute to the pathogenesis of autoimmunity b...
10 CitationsSource
#1Stephen Chu-Sung HuH-Index: 11
#2Hsin-Su YuH-Index: 32
Last. Cheng-Che E. LanH-Index: 21
view all 6 authors...
Neutrophil extracellular trap formation is increased in psoriasis and induces human β-defensin-2 production in epidermal keratinocytes
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Cited By1
Newest
Neutrophil extracellular traps (NETs) have been initially described as main actors in host defense owing to their ability to immobilize and sometimes kill microorganisms. Subsequent studies have demonstrated their implication in the pathophysiology of various diseases, in particular due to the toxic effects of their main components, histones and proteases, on surrounding tissues. Several distinct pathways in response to various triggers have been described. Among these triggers, IgG immune compl...
Source
#1Mitsuhiro Akiyama (Stanford University)H-Index: 1
#2Markus Zeisbrich (Stanford University)H-Index: 3
Last. Cornelia M. Weyand (Stanford University)H-Index: 101
view all 8 authors...
Objective: Granulomatosis with polyangiitis (GPA) is a multi-organ vasculitic syndrome typically associated with neutrophil extracellular trap (NET) formation and aggressive tissue inflammation and disruption. Head and neck (HN specifically, alarmin S100A9. NET-induced upregulation of monocyte S100A9 required recognition of DNA. S100A9 release resulted in the induction of metallo-proteinases, including MMP-9 and enabled monocytes to invade into extracellular matrix. Anti-MMP-9 treatment attenuat...
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