Abstract 2575: EZH2 mediates resistance to cisplatin in small cell lung cancer through nucleotide excision repair
Abstract
Small cell lung cancer (SCLC) is the most aggressive form of lung cancer, with a five-year survival rate of 7%. Cisplatin-based chemotherapy is the first line treatment for SCLC; however, many patients develop treatment resistance and experience tumor recurrence. Targeting proteins critical to the repair of cisplatin DNA crosslinks is a strategy for overcoming acquired cisplatin resistance in SCLC, but many proteins that mediate crosslink repair...
Paper Details
Title
Abstract 2575: EZH2 mediates resistance to cisplatin in small cell lung cancer through nucleotide excision repair
Published Date
Jul 1, 2019
Journal
Volume
79
Pages
2575 - 2575
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