Abstract 2036: Osteoblasts use multiple mechanisms of cellular communication to regulate breast cancer cell proliferation in bone

Breast cancer (BC) preferentially metastasizes to bone. While the mechanism for preferred metastasis is unknown, bone likely provides a hospitable environment that attracts BC cells (BCCs) and allows them to colonize and grow. Bone metastases perturb the balance of normal bone remodeling. Emerging evidence suggests that OBs may be altered and respond differently to cancer cells during metastatic BC progression. According to one study, OBs...