Activation of G0/G1 switch gene 2 by endoplasmic reticulum stress enhances hepatic steatosis

Perturbed endoplasmic reticulum (ER) homeostasis and increased levels of G0/G1 Switch Gene 2 (G0S2) have been documented in animal models with fatty liver disease. In this study, we investigated whether G0S2 is regulated by branch of the unfolded protein response (UPR) and contributes to ER stress-induced hepatic steatosis.We first analyzed G0S2 expression and the state of the three canonical UPR branches in several hepatic steatosis models,...