An Exaggerated Muscle Metaboreflex In Diabetic Rats Is Mediated By Potentiated Skeletal Muscle Afferent Responsiveness

Patients with type 2 diabetes (T2D) exhibit an excessive increase in blood pressure during exercise. Evidence suggests that the skeletal muscle metaboreflex is exaggerated in T2D. However, the underlying mechanisms remain poorly understood. Metaboreflex sensory signals from exercising muscle are generated by activation of chemically-sensitive group IV afferent neurons. It is logical to suggest, therefore, that heightened metaboreflex function in...