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Visual memory dysfunction as a neurocognitive endophenotype in bipolar disorder patients and their unaffected relatives. Evidence from a 5-year follow-up Valencia study.

Published on Oct 1, 2019in Journal of Affective Disorders4.08
· DOI :10.1016/j.jad.2019.06.059
Patricia Correa-Ghisays1
Estimated H-index: 1
,
Joan Vicent Sánchez-Ortí (University of Valencia)+ 13 AuthorsRafael Tabarés-Seisdedos49
Estimated H-index: 49
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Abstract
Abstract Background Scarce research has focused on Visual Memory (VM) deficits as a possible neurocognitive endophenotype of bipolar disorder (BD). The main aim of this longitudinal, family study with healthy controls was to explore whether VM dysfunction represents a neurocognitive endophenotype of BD. Methods Assessment of VM by Rey-Osterrieth Complex Figure Test (ROCF) was carried out on a sample of 317 subjects, including 140 patients with BD, 60 unaffected first-degree relatives (BD-Rel), and 117 genetically-unrelated healthy controls (HC), on three occasions over a 5-year period (T1, T2, and T3). BD-Rel group scores were analyzed only at T1 and T2. Results Performance of BD patients was significantly worse than the HC group ( p p p =0.05), and showed an intermediate profile between the BD and HC groups. Only among BD patients, there were significant differences according to sex, with females performing worse than males ( p =0.03). Regarding other variables, education represented significant differences only in average scores of BD-Rel group ( p =0.01). Limitations Important attrition in BD-Rel group over time was detected, which precluded analysis at T3. Conclusions BD patients show significant deficits in VM that remain stable over time, even after controlling sociodemographic and clinical variables. Unaffected relatives also show stable deficits in VM. Accordingly, the deficit in VM could be considered a potential endophenotype of BD, which in turn may be useful as a predictor of the evolution of the disease. Further studies are needed to confirm these findings.
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Published on Feb 1, 2019in Journal of Affective Disorders4.08
Amparo Tatay-Manteiga1
Estimated H-index: 1
,
Omar Cauli30
Estimated H-index: 30
(University of Valencia)
+ 3 AuthorsVicent Balanzá-Martínez25
Estimated H-index: 25
(University of Valencia)
Abstract Background Bipolar disorder (BD) is associated with significant neurocognitive and functional impairment, which may progress across stages. However, the potential progression of subjective cognitive complaints and quality of life (QoL) has not been addressed. Our main objective was to assess subjective cognitive complaints and QoL on euthymic patients with BD and their healthy siblings. Methods Four groups were compared: euthymic patients with type I BD in the early (n = 25) and late (n...
Published on Feb 1, 2019in Cns Spectrums3.94
Tamsyn E. Van Rheenen13
Estimated H-index: 13
,
Kathryn E. Lewandowski18
Estimated H-index: 18
+ 1 AuthorsKatherine E. Burdick43
Estimated H-index: 43
Published on Aug 1, 2018in Acta Psychiatrica Scandinavica4.69
J. Sánchez-Moreno47
Estimated H-index: 47
(University of Barcelona),
C.M. Bonnin24
Estimated H-index: 24
(University of Barcelona)
+ 13 AuthorsM. P. García-Portilla3
Estimated H-index: 3
(CSIC: Spanish National Research Council)
Published on Dec 1, 2017in Journal of Affective Disorders4.08
Ricardo Alexandre Toniolo5
Estimated H-index: 5
(USP: University of São Paulo),
Francy de Brito Ferreira Fernandes5
Estimated H-index: 5
(USP: University of São Paulo)
+ 2 AuthorsBeny Lafer32
Estimated H-index: 32
(USP: University of São Paulo)
Abstract Background Depressive episodes and cognitive impairment are major causes of morbidity and dysfunction in individuals suffering from bipolar disorder (BD). Novel treatment approaches that target clinical and cognitive aspects of bipolar depression are needed, and research on pathophysiology suggests that mitochondrial modulators such as the nutraceutical creatine monohydrate might have a therapeutic role for this condition. Methods Eighteen (N=18) patients with bipolar depression accordi...
Published on Jun 1, 2017in Journal of Affective Disorders4.08
Patricia Correa-Ghisays1
Estimated H-index: 1
(University of Valencia),
Vicent Balanzá-Martínez25
Estimated H-index: 25
(University of Valencia)
+ 11 AuthorsJ. Sánchez-Moreno47
Estimated H-index: 47
(University of Barcelona)
Abstract Background Few studies have examined Manual Motor Speed (MMS) in bipolar disorder (BD). The aim of this longitudinal, family study was to explore whether dysfunctional MMS represents a neurocognitive endophenotype of BD. Methods A sample of 291 subjects, including 131 BD patients, 77 healthy first-degree relatives (BD-Rel), and 83 genetically-unrelated healthy controls (HC), was assessed with the Finger-Tapping Test (FTT) on three occasions over a 5-year period. Dependence of FTT on par...
Published on Feb 1, 2017in Neuroscience & Biobehavioral Reviews8.00
Kamilla W. Miskowiak23
Estimated H-index: 23
(Copenhagen University Hospital),
Hanne L. Kjærstad4
Estimated H-index: 4
(Copenhagen University Hospital)
+ 6 AuthorsAndré F. Carvalho37
Estimated H-index: 37
(UFC: Federal University of Ceará)
Abstract The phenomenology and underlying pathophysiology of bipolar disorder (BD) are heterogeneous. The identification of putative endophenotypes for BD can aid in the investigation of unique patho-etiological pathways, which may lead to the development of personalised preventative and therapeutic approaches for this multi-faceted disorder. We included original studies involving unaffected first-degree relatives of BD patients (URs) and a healthy control (HC) comparison group with no first-deg...
Published on Oct 1, 2016in European Neuropsychopharmacology4.47
Kamilla W. Miskowiak23
Estimated H-index: 23
(Copenhagen University Hospital),
André F. Carvalho37
Estimated H-index: 37
(UFC: Federal University of Ceará)
+ 1 AuthorsLars Vedel Kessing50
Estimated H-index: 50
(Copenhagen University Hospital)
Abstract Cognitive dysfunction is an emerging treatment target in bipolar disorder (BD). Several trials have assessed the efficacy of novel pharmacological and psychological treatments on cognition in BD but the findings are contradictory and unclear. A systematic search following the PRISMA guidelines was conducted on PubMed and PsychInfo. Eligible articles reported randomized, controlled or open-label trials investigating pharmacological or psychological treatments targeting cognitive dysfunct...
Published on Aug 1, 2016in Journal of Neural Transmission2.90
Julia Volkert10
Estimated H-index: 10
(Goethe University Frankfurt),
J. Haubner1
Estimated H-index: 1
(University of Würzburg)
+ 4 AuthorsAndreas Reif50
Estimated H-index: 50
(Goethe University Frankfurt)
Previous studies have demonstrated impairments in attention, memory and executive functions in euthymic bipolar patients (BP) as well as their unaffected first-degree relatives, albeit in an attenuated form. Subsequently, cognitive deficits are discussed as a possible endophenotype of bipolar disorder. However, recent studies showed that only a subgroup of BP shows cognitive impairments. The aim of the present study was to investigate cognitive functioning in relatives compared to BP, to find ou...
Published on Jun 1, 2016in British Journal of Psychiatry7.23
Anna Georgiades6
Estimated H-index: 6
,
Fruhling Rijsdijk48
Estimated H-index: 48
+ 10 AuthorsColm McDonald49
Estimated H-index: 49
Background Twin studies have lacked statistical power to apply advanced genetic modelling techniques to the search for cognitive endophenotypes for bipolar disorder. Aims To quantify the shared genetic variability between bipolar disorder and cognitive measures. Method Structural equation modelling was performed on cognitive data collected from 331 twins/siblings of varying genetic relatedness, disease status and concordance for bipolar disorder. Results Using a parsimonious AE model, verbal epi...
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