Total Synthesis and Amyloid β Aggregation Inhibitory Activity of (−)-L-755,807

(−)-L-755,807, which was isolated from an endophytic fungus, Microsphaeropsis sp., consists of a characteristic epoxy-γ-lactam ring and a tetraene-containing side chain, and exhibits bradykinin B2 receptor antagonist activity. The first total synthesis of (−)-L-755,807 was accomplished through a convergent approach, employing a late-stage coupling between the ring and side-chain segments. The ring segment was efficiently synthesized by a novel...