The Promise of Selecting Individuals from the Extremes of Exposure in the Analysis of Gene-Physical Activity Interactions

<b><i>Background:</i></b> Dichotomization using the lower quartile as cutoff is commonly used for harmonizing heterogeneous physical activity (PA) measures across studies. However, this may create misclassification and hinder discovery of new loci. <b><i>Objectives:</i></b> This study aimed to evaluate the performance of selecting individuals from the extremes of the exposure (SIEE) as an...