Response to: ‘Can IL-1 be used as a target for osteoarthritis?’ by Cheng et al

We thank Cheng, Tian and Zhang1 for their interest in our article2 that showed that targeting interleukin (IL)-1α and IL-1β with lutikizumab did not significantly improve clinical and imaging outcomes in patients with inflammatory erosive hand osteoarthritis (HOA). The results of the study were indeed disappointing and, appropriately, should stimulate discussion about the role of IL-1 in osteoarthritis. In our trial, levels of IL-1 were...