The Impact of Prophylactic Lacosamide on LPS-Induced Neuroinflammation in Aged Rats

Volume: 42, Issue: 5, Pages: 1913 - 1924
Published: Jul 2, 2019
Abstract
Sepsis-induced central nervous system damage is called sepsis-associated encephalopathy (SAE). In addition to neuroinflammation, oxidative stress and apoptosis act in the development of SAE. In the current study, we evaluated the protective effects of lacosamide (LCM) on neuroinflammation induced by lipopolysaccharide (LPS). Twenty-four Wistar albino rats were divided into 3 groups as controls, LPS group (5 mg/kg i.p.), and LPS plus LCM group...
Paper Details
Title
The Impact of Prophylactic Lacosamide on LPS-Induced Neuroinflammation in Aged Rats
Published Date
Jul 2, 2019
Volume
42
Issue
5
Pages
1913 - 1924
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