Crucial role for central carbon metabolism in the bacterial L-form switch and killing by β-lactam antibiotics
Abstract
The peptidoglycan cell wall is an essential structure for the growth of most bacteria. However, many are capable of switching into a wall-deficient L-form state in which they are resistant to antibiotics that target cell wall synthesis under osmoprotective conditions, including host environments. L-form cells may have an important role in chronic or recurrent infections. The cellular pathways involved in switching to and from the L-form state...
Paper Details
Title
Crucial role for central carbon metabolism in the bacterial L-form switch and killing by β-lactam antibiotics
Published Date
Jul 8, 2019
Journal
Volume
4
Issue
10
Pages
1716 - 1726
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