RKI‐1447 suppresses colorectal carcinoma cell growth via disrupting cellular bioenergetics and mitochondrial dynamics

Accumulated evidence suggested the importance of the Rho/Rho‐kinase (ROCK) signaling pathway in cancer proliferation and invasion. However, its role in colorectal carcinoma (CRC) is not well understood. This study evaluated the effect of ROCK signaling pathway on CRC behavior on the basis of a novel Rho/ROCK inhibitor RKI‐1447. Here, we found RKI‐1447 could drastically suppress HCT‐8 and HCT‐116 cell growth and promoted apoptosis. Our in vitro...