Abstract 3373: Identification of KRAS membrane bound states using an integrated computational and experimental approach

Driver mutations in KRAS occur in almost 30% of human tumors, primarily in pancreatic, colorectal and lung tumors. These mutations result in increased cell proliferation and survival predominantly mediated through the MAPK signaling pathway. MAPK signal transduction is initiated by the interaction of RAF kinase with active RAS at the plasma membrane. The precise molecular details of this process are currently unknown. The Frederick National...