Novel Atg4B inhibitors potentiate cisplatin therapy in lung cancer cells through blockade of autophagy
Abstract
Autophagy induction in tumors is implicated in tumor malignancy and acquisition of anticancer-drug resistance, and hence, autophagy inhibitors are expected as novel anticancer agents. Atg4B, a cysteine proteinase, is a key enzyme in autophagy process, and considered as one of desirable targets for development of selective autophagy inhibitors. In this study, to search novel inhibitors of Atg4B, we employed the virtual screening approach and...
Paper Details
Title
Novel Atg4B inhibitors potentiate cisplatin therapy in lung cancer cells through blockade of autophagy
Published Date
Nov 1, 2019
Journal
Volume
12
Pages
100095 - 100095
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