Dynamic Views of the Fc Region of Immunoglobulin G Provided by Experimental and Computational Observations
Abstract
The Fc portion of immunoglobulin G (IgG) is a horseshoe-shaped homodimer, which interacts with various effector proteins, including Fcγ receptors (FcγRs). These interactions are critically dependent on the pair of N-glycans packed between the two CH2 domains. Fucosylation of these N-glycans negatively affects human IgG1-FcγRIIIa interaction. The IgG1-Fc crystal structures mostly exhibit asymmetric quaternary conformations with divergent...
Paper Details
Title
Dynamic Views of the Fc Region of Immunoglobulin G Provided by Experimental and Computational Observations
Published Date
Jul 1, 2019
Journal
Volume
8
Issue
3
Pages
39 - 39
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