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Tumor microenvironment and stroma in intestinal adenocarcinomas and associated metastases in Atlantic salmon broodfish (Salmo salar)

Published on Aug 1, 2019in Veterinary Immunology and Immunopathology 1.85
· DOI :10.1016/j.vetimm.2019.109891
Håvard Bjørgen2
Estimated H-index: 2
(NMBU: Norwegian University of Life Sciences),
Hege Hellberg + 3 AuthorsOle Bendik Dale12
Estimated H-index: 12
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Abstract
Abstract Animal models are invaluable tools in cancer research. In this context, salmon is a promising candidate. Intestinal adenocarcinoma with metastases may be induced as a consequence of a plant-based diet triggering the inflammation – dysplasia- carcinogenesis pathway. Here, we investigate the stroma and the presence and nature of immune cells in such tumors by staining for mast cells, immunohistochemistry for T cells and antigen-presenting cells and in situ hybridization for B cells. In intestinal tumors, substantial amounts of T cells were detected in the stroma, whilst MHC class II + cells were mainly among the cancerous cells. Ig + cells were observed primarily in the tumor periphery. Mast cells showed a strong association with stroma. In metastases, scarce amounts of T cells were detected, whilst MHC I and II-reactivity varied, some tumors being completely negative. Ig + cells were scattered around the metastatic tissue in no particular pattern, but were occasionally observed within clusters of tumor cells. Small numbers of mast cells were detected in the stroma. To the best of our knowledge, this is the first report addressing immune cells in fish tumors. The teleost tumor microenvironment seems comparable to that of mammals, making fish interesting model animals in oncoimmunology research.
  • References (39)
  • Citations (0)
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References39
Newest
Published on Jan 1, 2019in British Journal of Cancer 5.42
Nicolas A. Giraldo2
Estimated H-index: 2
(JHUSOM: Johns Hopkins University School of Medicine),
Rafael Sanchez-Salas21
Estimated H-index: 21
+ 8 AuthorsWolf H. Fridman64
Estimated H-index: 64
(Paris V: Paris Descartes University)
The highly complex and heterogenous ecosystem of a tumour not only contains malignant cells, but also interacting cells from the host such as endothelial cells, stromal fibroblasts, and a variety of immune cells that control tumour growth and invasion. It is well established that anti-tumour immunity is a critical hurdle that must be overcome for tumours to initiate, grow and spread and that anti-tumour immunity can be modulated using current immunotherapies to achieve meaningful anti-tumour cli...
Published on Jul 1, 2018in Journal of Fish Diseases 1.99
Håvard Bjørgen2
Estimated H-index: 2
(NMBU: Norwegian University of Life Sciences),
Erling Olaf Koppang20
Estimated H-index: 20
(NMBU: Norwegian University of Life Sciences)
+ 4 AuthorsOle Bendik Dale12
Estimated H-index: 12
Published on Apr 1, 2018in Journal of Fish Diseases 1.99
Adam R. Burns9
Estimated H-index: 9
(UO: University of Oregon),
Virginia G. Watral19
Estimated H-index: 19
(OSU: Oregon State University)
+ 6 AuthorsMichael L. Kent51
Estimated H-index: 51
(OSU: Oregon State University)
Intestinal neoplasms are common in zebrafish (Danio rerio) research facilities. These tumours are most often seen in older fish and are classified as small cell carcinomas or adenocarcinomas. Affected fish populations always contain subpopulations with preneoplastic lesions, characterized by epithelial hyperplasia or inflammation. Previous observations indicated that these tumours are unlikely caused by diet, water quality or genetic background, suggesting an infectious aetiology. We performed f...
Abdulrahman Saadalla5
Estimated H-index: 5
(Mayo Clinic),
Abu Osman1
Estimated H-index: 1
(Mayo Clinic)
+ 7 AuthorsKhashayarsha Khazaie9
Estimated H-index: 9
(Mayo Clinic)
Mast cells (MCs) are tissue resident sentinels that mature and orchestrate inflammation in response to infection and allergy. While they are also frequently observed in tumors, the contribution of MCs to carcinogenesis remains unclear. Here, we show that sequential oncogenic events in gut epithelia expand different types of MCs in a temporal-, spatial-, and cytokine-dependent manner. The first wave of MCs expands focally in benign adenomatous polyps, which have elevated levels of IL-10, IL-13, a...
Claire Vergneau-Grosset4
Estimated H-index: 4
(UdeM: Université de Montréal),
Marie-Eve Nadeau7
Estimated H-index: 7
(UdeM: Université de Montréal),
Joseph M. Groff2
Estimated H-index: 2
(Veterinary Medical Teaching Hospital)
Published on Oct 12, 2016in Anticancer Research 1.94
Juliana Knief3
Estimated H-index: 3
,
Katharina Reddemann3
Estimated H-index: 3
+ 3 AuthorsChristoph Thorns18
Estimated H-index: 18
Background: Tumor-infiltrating lymphocytes (TILs) have been shown to be of prognostic significance in a variety of tumors. Not only T-cell, but also B-cell infiltration is commonly associated with improved survival. Materials and Methods: We assessed the density of tumor-infiltrating B-cells, as well as that of plasma cells, in 210 adenocarcinomas of the esophagogastric junction through immunohistochemical analysis using antibodies against CD20 and CD138. Results: No correlation between density ...
Published on Feb 23, 2015in Frontiers in Immunology 4.72
Claire Germain11
Estimated H-index: 11
(Paris V: Paris Descartes University),
Sacha Gnjatic57
Estimated H-index: 57
(ISMMS: Icahn School of Medicine at Mount Sinai),
Marie-Caroline Dieu-Nosjean39
Estimated H-index: 39
(Paris V: Paris Descartes University)
It is now admitted that the immune system plays a major role in tumor control. Besides the existence of tumor-specific T cells and B cells, many studies have demonstrated that high numbers of tumor-infiltrating lymphocytes are associated with good clinical outcome. In addition, not only the density but also the organization of tumor-infiltrating immune cells has been shown to determine patient survival. Indeed, more and more studies describe the development within the tumor microenvironment of t...
Published on Jan 1, 2015
Nelson Shu-Sang Yee21
Estimated H-index: 21
,
Natalia A. Ignatenko22
Estimated H-index: 22
+ 2 AuthorsDouglas B. Stairs16
Estimated H-index: 16
Published on Nov 1, 2014in Developmental and Comparative Immunology 3.12
Guro Løkka4
Estimated H-index: 4
(NMBU: Norwegian University of Life Sciences),
Lars Austbø10
Estimated H-index: 10
(NMBU: Norwegian University of Life Sciences)
+ 5 AuthorsErling Olaf Koppang20
Estimated H-index: 20
(NMBU: Norwegian University of Life Sciences)
Abstract Forming a barrier to the outside world, the gut mucosa faces the challenge of absorbing nutrients and fluids while initiating immune reactions towards potential pathogens. As a continuation to our previous publication focusing on the regional intestinal morphology in wild caught post smolt and spawning Atlantic salmon, we here investigate selected immune parameters and compare wild, reared unvaccinated and vaccinated post smolts. We observed highest transcript levels for most immune-rel...
Published on Jul 15, 2014in Oncotarget
Alexander Shimabukuro-Vornhagen17
Estimated H-index: 17
,
Hans Anton Schlößer6
Estimated H-index: 6
+ 16 AuthorsAnne Fiedler5
Estimated H-index: 5
('.header-date').hide();'#titleAuthors').hide(); $('#abstractHeader').hide(); Alexander Shimabukuro-Vornhagen 1 , 2 , * , Hans A. Schloser 1 , 3 , * , Luise Gryschok 1 , Joke Malcher 1 , Kerstin Wennhold 1 , Maria Garcia-Marquez 1 , Till Herbold 1 , 3 , Laura S. Neuhaus 1 , Hans J. Becker 1 , Anne Fiedler 1 , Pascal Scherwitz 4 , Thomas Koslowsky 5 , Roland Hake 6 , Dirk L. Stippel 3 , Arnulf H. Holscher 3 , Sebastian Eidt 6 , Michael Hallek 2 , Sebastian Theurich 1 , 2 , Michael S. von Bergw...
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