Rational design using sequence information only produces a peptide that binds to the intrinsically disordered region of p53
Abstract
Intrinsically disordered regions (IDRs) of proteins are involved in many diseases. The rational drug design against disease-mediating proteins is often based on the 3D structure; however, the flexible structure of IDRs hinders the use of such structure-based design methods. Here, we developed a rational design method to obtain a peptide that can bind an IDR using only sequence information based on the statistical contact energy of amino acid...
Paper Details
Title
Rational design using sequence information only produces a peptide that binds to the intrinsically disordered region of p53
Published Date
Jun 28, 2019
Journal
Volume
9
Issue
1
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