Can GBA1-Associated Parkinson Disease Be Modeled in the Mouse?

Mutations in GBA1, the gene encoding the lysosomal lipid-degrading enzyme GCase, increase the risk for developing Parkinson disease (PD). The mechanisms by which GBA1 mutations induce susceptibility to PD are still not clear, in part because of the challenges in generating appropriate disease models. GCase is reduced in PD brains in the absence of GBA1 mutations, highlighting the inverse relationship between GCase and α-synuclein, and the...